| ncRNA name | AMPK siRNA |
| ncRNA Category | siRNA |
| Disease name | uveal melanoma (UM) |
| Species | Homo sapiens |
| Tissues/Cell_line | primary choroidal UM cell line: Mel202, Mel270, Mel290, 92.1 and OCM1A; liver metastasis cell line from Mel270: Omm1.3 |
| Methods | CCK-8 assay, flow cytometry, colony assay, apoptosis assay, transfection, immunoblot |
| Expression pattern | associated |
| Functional description | The downregulation of AMPK by siRNA or its inhibition with compound C did not rescue the cells from autophagy, rather they died by apoptosis, defining AMPK as a key regulator of mutant GNAQ signaling and a switch between autophagy and apoptosis. |
| PubMed ID | 23443802 |
| Year | 2013 |
| Title | Inhibition of mutant GNAQ signaling in uveal melanoma induces AMPK-dependent autophagic cell death. |
| Drug-related ncRNA | NO |
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